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ea0032p622 | Growth hormome IGF axis – basic | ECE2013

A comparison of the in vitro production of IGFs, IGFBP-4 and PAPP-A in cultures of visceral and subcutaneous adipose tissue fragments from obese subjects

Frystyk Jan , Gude Mette Faurholdt , Hjortebjerg Rikke , Oxvig Claus , Pedersen Steen Bonlokke

Background: Visceral adipose tissue (VAT) is less insulin sensitive and more harmful than subcutaneous adipose tissue (SAT). In adipocytes, IGF1 receptor signaling has been linked to insulin resistance, but it is unknown whether VAT and SAT also differ in production of IGFs. Therefore, we compared IGFs, IGFBP-4 and PAPP-A production in cultured fragments of VAT and SAT from obese subjects.Methods: VAT and SAT was collected perioperatively during elective...

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ea0034ja1 | Society for Endocrinology Journal Award ‐ <emphasis role="italic">Journal of Endocrinology</emphasis> | SFEBES2014

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader Jessica R , Resch Zachary T , McLean Gary R , Mikkelsen Jakob H , Oxvig Claus , Marler Ronald J , Conover Cheryl A

Journal of Endocrinology 2013 219 5158. DOI: 10.1530/JOE-13-0167...

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Endocrine Abstracts

A comparison of the in vitro production of IGFs, IGFBP-4 and PAPP-A in cultures of visceral and subcutaneous adipose tissue fragments from obese subjects

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

BiosciAbstracts